Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity

Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity

Saturday, April 4, 2020 • 8:30 AM - 11:30 AM

SDCC, Room 3

Chair: Philip Iannaccone, MD, PhD • Northwestern University Medical School
Co-Chairs: Qin Yan, PhD • Yale School of Medicine
David C. Williams, Jr., MD, PhD • University of North Carolina, Chapel Hill

Session Description: Recent advances in transcriptomics have shown that gene expression states vary tremendously from cell to cell. This variation is essential in development where the specification of fate depends on controlled heterogeneity. In cancer, genetic and epigenetic changes results in highly heterogeneous expression states despite clonal origins. This session will present the emerging single-cell technologies in transcriptomics and epigenomics, data analysis pipeline, and the biological significance of these data.

  • Chair - Welcome and Introductions
  • 8:30 AM - 9:15 AM
    Single-Cell Genomics in Cancer Immunotherapy
    Ansu Satpathy, MD, PhD • Stanford University
  • 9:15 AM - 10:00 AM
    Single Cell Epigenomic Analysis of the Anatomy and Neuronal Circuitry of the Brain
    Joseph Ecker, PhD • Salk Institute
  • 10:00 AM - 10:45 AM
    Integrative RNA and Chromatin Analysis of Single Cells in Human Tissues
    Kun Zhang, PhD • Salk Institute
  • 10:45 AM - 11:30 AM
    Methods for Calibration, Imputation, Visualization and Differentiation Between Samples in scRNA-seq Data Analysis
    Yuval Kluger, PhD • Yale University
  • Questions and Answers