Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity
SDCC, Room 3

Chair: Philip Iannaccone, MD, PhD • Northwestern University Medical School
Co-Chairs: Qin Yan, PhD • Yale School of Medicine
David Williams, MD, PhD • University of North Carolina, Chapel Hill

Session Description:  Recent advances in transcriptomics have shown that gene expression states vary tremendously from cell to cell. This variation is essential in development where the specification of fate depends on controlled heterogeneity. In cancer, genetic and epigenetic changes results in highly heterogeneous expression states despite clonal origins. This session will present the emerging single-cell technologies in transcriptomics and epigenomics, data analysis pipeline, and the biological significance of these data. See speakers and presentation titles

Minisymposium: Pathobiology of Cancer
SDCC, Room 4

Abstract-Driven Short Talks (15-minutes each)

Symposium: The Gut Microbiota and Disease - Session I
SDCC, Room 2

Chairs: Xiao-Ming Yin, MD, PhD • Indiana University School of Medicine
Co-Chairs: Wenke Feng, PhD • University of Louisville
Maria Pilar Alcaide, PhD • Tufts University School of Medicine
José Otero, MD, PhD • The Ohio State University

Session Description:  Humans carry a vast number of bacteria and other microbiota species from birth, and you may be more bacteria than you are you. An increasing importance of microbiota in human health and diseases has been recognized. Whatever your research subjects are, chances are that they may be influenced by the microbiota. This symposium will discuss the impact of gut microbiota on diseases ranging from neurodegeneration to diabetes, from the liver to the heart, and from the immune cells to the bone. See speakers and presentation titles

Minisymposium: Pathobiology of Cardiovascular Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

ASIP Highlights Session: I Am An ASIP Member and This Is My Science
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Marina Ballroom, Salon G

Chair: Edward A. Medina, MD, PhD • University of Texas Health Science Center
Co-Chair: Titus A. Reaves, PhD • Medical University of South Carolina
Nakisha Rutledge, BSc • Northwestern University

Session Description:  As a Society, we cannot escape the identity crisis we have confronted in the past - what is pathology and how do pathologists fit into the basic framework of biomedical science? This is an ongoing challenge that requires our members to educate others regarding the nature of the discipline of experimental pathology and how our research describes and investigates the pathology, pathogenesis, and pathophysiology of specific diseases at the molecular, cellular, organ, and organismal level. Overcoming this identity crisis requires effort on the part of each ASIP member and our success will be evident as we continue to attract bright and enthusiastic young investigators into the diverse field of experimental pathobiology.

The American Society for Investigative Pathology presents I Am An ASIP Member and This Is My Science a dynamic and inspiring session featuring ASIP Scientists on the Cutting Edge of Discovery briefly, present their research, accomplishments, career journeys, and service to ASIP. This session highlights the diversity among our membership, and provides trainees, young scientists, pathologists, and the members of the larger scientific community the opportunity to become inspired by Trailblazers in the field of investigative pathology. See speakers and presentation titles

Symposium: Disease Modeling with iPSC: From Cells to Organoids
SDCC, Room 3

Chair: Philip M. Iannaccone, MD, PhD • Northwestern University Medical School
Co-Chairs: Satdarshan Paul Singh Monga, MD • University of Pittsburgh School of Medicine
Ivana Delalle, PhD, MD • Boston University School of Medicine

Session Description:  The availability of human iPSC from various disease states presents an unprecedented opportunity to examine pathology and physiology in an intact tissue context. The decades since the early descriptions of stem cell derived “embryoid bodies”, the first example of “organoids”, have seen major advances in directed differentiation of stem cells and their organization into small structures mimicking normal organs. Organoids can be used to interrogate altered physiology and toxicology or as test beds for therapeutic intervention. Patient derived iPSC have been used to advance our understanding of many aspects of disease states. This session will highlight recent advances in both organoids and the use of directed differentiation of human iPSC in the study of disease. See speakers and presentation titles

Symposium: The Gut Microbiota and Disease - Session II
SDCC, Room 2

Chair: Xiao-Ming Yin, MD, PhD • Indiana University School of Medicine
Co-Chairs: Wenke Feng, PhD • University of Louisville
Maria Pilar Alcaide, PhD • Tufts University School of Medicine
José Otero, MD, PhD • The Ohio State University

Session Description:  Humans carry a vast number of bacteria and other microbiota species from birth, and you may be more bacteria than you are you. An increasing importance of microbiota in human health and diseases has been recognized. Whatever your research subjects are, chances are that they may be influenced by the microbiota. This symposium will discuss the impact of gut microbiota on diseases ranging from neurodegeneration to diabetes, from the liver to the heart, and from the immune cells to the bone. See speakers and presentation titles

Minisymposium: Neuropathobiology
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Women in Pathology Social
SDCC, Rooms 2-5 Foyer

Leader: Linda McManus, PhD • University of Texas Health San Antonio
Co-Leaders: Maria Pilar Alcaide, PhD • Tufts University School of Medicine
Nakisha Rutledge, BSc • Northwestern University

Social Description:  Women in Pathology is a new community within the membership of the American Society for Investigative Pathology (ASIP) that is focused on issues that face women in science, and is committed to recognizing women’s scientific achievements and fostering their career development and advancement in pathobiology research. Women in Pathology will address challenges for women in science at every stage of career and life – as trainees, as active biomedical researchers, during transitions into career breaks required for family life, during transitions back into professional life as a mother, and as advanced investigators. Women in Pathology will provide innovative opportunities for engagement by women in science to participate in productive networking, development of meaningful professional partnerships, and mentoring.

EB-Wide Tang Prize Award Lecture
Tyrosine Phosphorylation - From Discovery to Drug Development and Beyond

Tony Hunter, PhD • Salk Institute for Biological Studies

EB-Wide Welcome Reception
SDCC, Sails Pavilion

The AJP Editorial Board Dinner
(By Invitation Only)
Roy's Waterfront Restaurant

ASIP Committee for Career Development and Diversity (CCDD) and Education Committee Meeting
SD Marriott Marquis & Marina • Del Mar Meeting Room

Histochemical Society Leadership Meeting
SDCC, Room 5B

Blood Vessel Club™ Gut Microbiota in Vascular Disease
Sponsored by the ASIP Inflammation/Immunopathology Scientific Interest Group and the Vascular and Mucosal Pathobiology Scientific Interest Group
SDCC, Room 3

Chair: Jonathon W. Homeister, MD, PhD • University of North Carolina at Chapel Hill
Co-Chair: Denuja Karunakaran, PhD • The University of Queensland

Session Description:  This symposium explores the newest discoveries into the role the gut microbiome has in the pathobiology of vascular diseases. Presentations by national and international experts in the field will focus on the mechanisms by which the gut microbiome can modulate both atherosclerotic vascular disease and hypertensive vascular disease. See speakers and presentation titles

Young Scientist Leadership Award Lecture
[Presented in conjunction with the Blood Vessel Club™  Gut Microbiota in Vascular Disease Session]

• Chair Introduction
• RIP Kinases in Cardiometabolic Diseases
  Denuja Karunakaran, PhD • The University of Queensland, Brisbane, Australia

Breast Cancer Workshop - Tumor Microenvironment in Breast Cancer Progression
Sponsored by the ASIP Breast Cancer Scientific Interest Group
SDCC, Room 2

Chair: Bethany Hannafon, BS, PhD • University of Oklahoma Health Sciences Center
Co-Chair: Piyali Dasgupta, PhD • Marshall University

Session Description:  This session will examine the role of the tumor microenvironment in primary breast cancer development to metastatic dissemination and therapeutic resistance. Attendees will hear from leaders in the breast cancer field about tumor-host crosstalk mediated by extracellular vesicles, the role of the immune microenvironment in cancer progression, tumor cell dormancy and its role in therapeutic resistance, and the role of the lymph node tumor microenvironment in the progression of lymph node breast cancer metastases. See speakers and presentation titles

Outstanding Investigator Award Lecture
[Presented in conjunction with the Breast Cancer Workshop]
SDCC, Room 2

• Introduction
• Understanding Breast Cancer: My Journey as a Physician-Scientist
  Celina Kleer, MD • University of Michigan

Society of Toxicologic Pathology (STP) Symposium: Animal models in Basic Research and Preclinical Science: The Critical Role of the Toxicologic Pathologist
Sponsored by the ASIP Environmental and Toxicologic Pathology Scientific Interest Group
SDCC, Room 5A

Chair: Mark Hoenerhoff, DVM, PhD • University of Michigan
Co-Chair: Jack Harkema, PhD, DVM • Michigan State University

Session Description:  Veterinary toxicologic pathologists play an integral role in biomedical and basic sciences, through translation of preclinical in vivo data for the study of human disease, development of new technologies and medical interventions, and drug development. Toxicologic pathologists also play a role in determination of chemical/drug adversity in animals and humans, and help predict relevance to humans taking into account mechanisms and margin of safety.

Working with researchers, clinicians, and toxicologists, toxicologic pathologists can help facilitate a better understanding of disease processes through interpretation of animal models, drug development, and improve translatability of preclinical data in the “bench to bedside” approach to patient care. Through expanding interdisciplinary collaborations with the human medical field and other disciplines, toxicologic pathologists are central to the “One Health” concept at the intersection of all aspects of health care for humans, animals, and environmental health. This session will showcase the role veterinary toxicologic pathologists play in basic research, investigative pathology, drug development, and imaging modalities to strengthen translatability of animal data to the clinic in collaboration with other scientists. This session will also highlight how toxicologic pathologists can inform on the validity, use, relevance, and power of animal models to study human disease. See speakers and presentation titles

Symposium: The Great Debate - Fibrosis Across Organs: Triggers, Pathways, and Cellular Plasticity
Co-Sponsored by the American Society for Matrix Biology (ASMB)
SDCC, Room 4

Chair: Titus A. Reaves, PhD • Medical University of South Carolina
Co-Chair: Tirthadipa Pradhan-Sundd, PhD • University of Pittsburgh

Session Description:  Fibrosing diseases are a broad spectrum of entities from organ-specific involvement to multi-system diseases with high morbidity and mortality and significantly unmet clinical needs. Progress in elucidating the pathogenesis of the fibroproliferative components across various diseases, including the critical roles of key cell types and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis, has highlighted many new areas of therapeutic investigation and are currently underway. This session is designed to bring together translational biomedical researchers from a wide range of disciplines to discuss complex pathophysiologic mechanisms that underlie fibrosing diseases. You won’t want to miss the hot topic debate on Power Cell – Fibroblast or Macrophage that will follow the session talks. See speakers and presentation titles

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

• Cancer I
• Inflammation and Disease
• Liver Pathobiology I
• Mucosal/Epithelial Pathobiology
• Neuropathology
• Stroke
• The Science of Diabetes

Planning for Success: Navigating Your First Faculty Position
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Carlsbad Cardiff

Chair: Christi Kolarcik, PhD • University of Pittsburgh
Co-Chair: Traci Parry, PhD • University of North Carolina at Greensboro

Session Description:  Feeling overwhelmed as you wrangle your first faculty position? Come hear from our experienced faculty as they impart valuable advice and tactics on successfully planning, transitioning into, adapting, (and surviving!) your first years as a faculty member. See speakers and presentation titles

Symposium: Fixing Fatty Liver
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group
SDCC, Room 2

Chair: Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh School of Medicine

Session Description:  In this session, we will approach the problem of non-alcoholic fatty liver disease (NAFLD) through improved understanding of the cellular and molecular mechanisms involved in disease progression. Recent advances in gut-liver axis, microbiome, and inflammation in the pathogenesis of NAFLD will be also discussed. Finally, we will explore novel signaling pathways that can be targeted for treatment of NAFLD. See speakers and presentation titles

Symposium: Novel Regulators and Functions of Epithelial Junctions
SDCC, Room 4

Chair: Sean Colgan, PhD • University of Michigan
Co-Chair: William Muller, MD, PhD • Northwestern University

Session Description:  Epithelial junctions are key regulators of tissue integrity and homeostasis, and their compromise contributes to the pathogenesis of inflammatory and immune disorders. This symposium will highlight recent developments in this exciting area of research and will touch upon developmental and disease pathways. The talks will cover the role of intercellular junction proteins in a range of tissues, including simple and complex epithelia. See speakers and presentation titles

Pathobiology Course for Research Scientists: Resolution of Inflammation
Sponsored by the ASIP Education Committee
SDCC, Room 5A

Chair: Dipak Panigrahy, MD • Beth Israel Deaconess Medical Center/Harvard Medical School
Co-Chair: Alexander Sougiannis, BS, MA • University of South Carolina School of Medicine

Session Description:  Unresolved inflammation is a major mechanism of pathogenesis in many human diseases. A paradigm shift is emerging in our understanding of the pathogenesis of inflammation which results not only from persistent activation of inflammatory signals, but also from the active loss of pro-resolution mechanisms. Differentiating between the suppression and resolution of inflammation driven by pro-resolution mediators is critical for the treatment of various inflammatory diseases. See speakers and presentation titles

Symposium: Coagulation and Fibrinolytic Factors and Innate Immunity
SDCC, Room 3

Chair: Wendy Mars, PhD • University of Pittsburgh Medical School
Co-Chair: Steven Gonias, MD, PhD • University of California, San Diego

Session Description:  Proteins involved in both the coagulation and fibrinolysis pathways do much more than their well-described historical roles affecting the formation and dissolution of clots. This session will highlight data from leaders in the field who are studying the function of hemostasis factors in innate immunity. See speakers and presentation titles

Rous-Whipple Award Lecture
SDCC, Room 2

• Introduction
• Exploring Precision Oncology: From Gene Fusions to Genomic Instability
  Arul Chinnaiyan, MD, PhD • University of Michigan

Scientific Interest Groups (SIG) Interactive Poster Discussions, Networking Sessions, Award Presentations and Reception
Room TBD

Interactive Discussions of Invited Posters Presenters which Represent the SIGs of the ASIP

Club Hepatomania™ - Meet the Liver Experts
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group
SDCC, Ballroom BC

Histochemical Society Business Meeting, Awards Presentations, and Reception
Horton Grand Hotel Atrium

ASIP Town Hall Meeting and Breakfast
SDCC, Room 5A

Chair: Dani S. Zander, MD • University of Cincinnati Medical Center
Co-Chair: William B. Coleman, PhD • American Society for Investigative Pathology

Session Description:  Are you a new member of the ASIP and want to become more involved? Are you interested in working with the ASIP leadership and committees? Join us for breakfast and open conversation in a casual enviorment where we network together with the common goal of building a stronger ASIP.

Minisymposium: Pathobiology of Lung Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Symposium: Emerging Technologies From the Bench Disrupting Diagnosis and Care Near the Bedside
SDCC, Room 2

Chair: Nathan Montgomery, MD, PhD • University of North Carolina, Chapel Hill
Co-Chair: Gregory Tsongalis, PhD • Dartmouth-Hitchcock Health System

Session Description:  This session will explore emerging genomic and molecular diagnostic tools that are being rapidly adopted in patient care, in the process transforming and disrupting the standard approach to clinical challenges as diverse as newborn diagnostics, microbiology, and oncology. See speakers and presentation titles

Symposium: Mechanisms of Hepatic Turmorigenesis
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group
SDCC, Room 3

Chair: Satdarshan Paul Singh Monga, MD • University of Pittsburgh School of Medicine
Co-Chair: Heather Francis, PhD, FAASLD • Indiana University

See speakers and presentation titles

VAMP Symposium: Immune Regulation of Barrier Forming Cells
Sponsored by the ASIP Vascular and Mucosal Pathobiology Scientific Interest Group
SDCC, Room 4

Chair: Jennifer Brazil, PhD • University of Michigan
Co-Chair: Francis W. Luscinskas, PhD • Brigham & Women's Hospital

See speakers and presentation titles

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

• Cancer II
• Cell Death, Injury, and Repair
• Environmental and Toxicological Pathology
• Infectious Disease I
• Liver Pathobiology II
• Lung Pathobiology
• Vascular Biology

Cotran Early Career Investigator Award Lecture
SDCC, Room 5A

• Introduction
• Studying Oxygen Sensing Pathway in Cancers
  Qing Zhang, PhD • UT Southwestern Medical Center

Workshop: Career Speed-Networking Luncheon: Conversations with Experts
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • San Diego Ballroom, Salon A

Chair: Verónica Contreras-Shannon, PhD • St. Mary's University
Co-Chair: Morgan Preziosi, BS, BA • University of Pennsylvania Perelman School of Medicine

Session Description:  From Academia to Patent Law, at this speed-networking lunch event, you'll have the chance to discuss diverse career opportunities, what skills you need to be successful in these careers, how to get your foot in the door, and so much more! See speakers and presentation titles

HCS, ASIP, AAA Symposium: Geographic Information System (GIS) for Tissues and Tumors: Mapping Quantitative Data into an Anatomical Context
SDCC, Room 6E

See speakers and presentation titles

Young Scientist Leadership Award Lecture
SDCC, Room 4

• Chair Introduction
• Exercise Oncology: Harnessing the Therapeutic Benefits of Exercise
  Traci L. Parry, PhD • University of North Carolina at Greensboro

The Journal of Histochemistry & Cytochemistry Lecture
SDCC, Room 6E

Chair: Stephen Hewitt, MD, PhD • Editor, Journal of Histochemistry and Cytochemistry • National Cancer Institute/National Institutes of Health

Session Description:

• Gender Diversity in Innovation Toolkit Created by IPO
  Mercedes K. Meyer, PhD, JD • Drinker Biddle and Reath, LLP

Presidential Symposium: Advances in Regenerative Medicine
SDCC, Room 2

Chair: Carol Farver, MD • Cleveland Clinic
Co-Chair: James Stone, MD, PhD • Massachusetts General Hospital

See speakers and presentation titles

Symposium: Deep Learning and Artificial Intelligence in Pathology
SDCC, Room 3

Chair: Stanley Cohen, MD • Rutgers-New Jersey Medical School
Co-Chair: John Tomaszewski, MD • University at Buffalo School of Medicine

See speakers and presentation titles

Minisymposium: Pathobiology of Cancer II
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

ASIP Business Meeting, Awards Presentations, and Reception
SDCC, Room 2

ASIP President’s Reception
Room TBD (By Invitation Only)

ASIP Program Committee Meeting
San Diego Marriott Marquis & Marina • Del Mar Meeting Room

XX^th Annual Workshop in Graduate Education in Pathology
Sponsored by the ASIP Education Committee
San Diego Marriott Marquis & Marina • Marina Ballroom, Salon D

Chair: Titus A. Reaves, PhD • Medical University of South
Co-Chair: José Otero, MD, PhD • The Ohio State University

See speakers and presentation titles

Minisymposium: Epithelial and Mucosal Pathobiology I
SDCC, Room 14B

Abstract-Driven Short Talks (15-minutes each)

Liver Pathobiology I
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Symposium: Precision Oncology: The Promise for Translating Personal Genomics into Clinical Action
SDCC, Room 4

Chair: Kevin Gardner, MD, PhD • Columbia University Medical Center
Co-Chair: Elizabeth Whitley, DVM, PhD • MD Anderson Cancer Center

See speakers and presentation titles

Symposium: Drinking from the Firehose: Progress in the Practical Uses of Big Data
SDCC, Room 2

Chairs: Dan Milner, Jr., MD, MSc, FASCP • American Society for Clinical Pathology
Co-Chair: Kevin Gardner, MD, PhD • Columbia University Medical Center

See speakers and presentation titles

ACVP-ASIP Symposium: Hemostasis and Thrombosis
Sponsored by the ASIP Veterinary and Comparative Pathology Scientific Interest Group and the American College of Veterinary Pathologists (ACVP)
SDCC, Room 3

Chair: Nora L. Springer, DVM, DACVP • Kansas State University College
Co-Chair: Katherine N. Gibson-Corley, DVM, PhD, DACVP • University of Iowa

Session Description:  Veterinary scientists discuss cutting edge research in canine hemostasis and thrombosis and correlate to the equivalent human disease. See speakers and presentation titles

ASIP Scientific Sleuthing of Human Disease for Undergraduate Students and High School Teachers and Students
Sponsored by the ASIP Education Committee
SD Marriott Marquis & Marina • Marina Ballroom, Salon G

Chair: Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh School of Medicine
Co-Chair: Martha B. Furie, PhD • Stony Brook University

See speakers and presentation titles

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

• Bioinformatics and Pathology Education
• Cardiac Pathobiology
• Endocrine Pathology
• Gene Expression
• Hemostasis and Thrombosis
• Infectious Disease II
• Metabolic Disorders
• Microscopy and Imaging
• Renal Pathology
• Veterinary Pathology

Lunch and Learn: The ABC of the IDP, A Mentoring Workshop
Sponsored by the ASIP Education Committee and the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Marriiott Grand Ballroom 1-2

Chair: Roberto Ivan Mota Alvidrez, MD, MS • University of North Carolina at Chapel Hill
Co-Chair: Christi Kolarcik, PhD • University of Pittsburgh

See speakers and presentation titles

SCVP-ASIP Joint Symposium: Clonal Hematopoiesis: Impact on Inflammation and Cardiovascular Disease - Cardiac Pathology
Sponsored by the ASIP Inflammation/Immunopathology Scientific Interest Group and the Society for Cardiovascular Pathology (SCVP)
SDCC, Room 2

Chair: James Stone, MD, PhD • Massachusetts General Hospital

See speakers and presentation titles

SIPMeT Symposium: Epigenetic Regulation and Cancer
Sponsored by ASIP and the Società Italiana di Patologia e Medicina Traslazionale/Italian Society of Pathology and Translational Medicine (SIPMeT)
Co-Sponsored by the ASIP Gene Regulation Scientific Interest Group
SDCC, Room 3

Chair: Massimiliano Corsi Romanelli, PhD, MD • University of Milan, Milan Italy
Co-Chair: Fancesco Curcio, MD • University of Udine, Udine, Italy

See speakers and presentation titles

Minisymposium: Liver Pathobiology II
SDCC, Room 4

Abstract-Driven Short Talks (15-minutes each)

Minisymposium: Pathobiology of Infectious Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Minisymposium: Epithelial and Mucosal Pathobiology II
SDCC, Room 14BA

Abstract-Driven Short Talks (15-minutes each)