ASIP 2020 Preliminary Program

ASIP 2020 Preliminary Program

SYMPOSIA AND WORKSHOP SESSIONS

Click on the links below to go directly to that day's agenda

Saturday   |   Sunday   |   Monday   |   Tuesday

Printable Consolidated Agenda

 

Saturday, April 4, 2020

 

8:30 AM - 11:30 AM

Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity
SDCC, Room 3

Chair: Philip Iannaccone, MD, PhD • Northwestern University Medical School
Co-Chairs: Qin Yan, PhD • Yale School of Medicine
David Williams, MD, PhD • University of North Carolina, Chapel Hill

Session Description:  Recent advances in transcriptomics have shown that gene expression states vary tremendously from cell to cell. This variation is essential in development where the specification of fate depends on controlled heterogeneity. In cancer, genetic and epigenetic changes results in highly heterogeneous expression states despite clonal origins. This session will present the emerging single-cell technologies in transcriptomics and epigenomics, data analysis pipeline, and the biological significance of these data. See speakers and presentation titles

8:30 AM - 10:30 AM

Minisymposium: Pathobiology of Cancer
SDCC, Room 4

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
8:30 AM - 8:45 AM A. Sougiannis Natural Anthraquinone Emodin May Protect Immune and Gastrointestinal Health During Chemotherapy Treatment 520
8:45 AM - 9:00 AM N. Naydenov Annilin regulates breast cancer cell migration, growth and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation 2266
9:00 AM - 9:15 AM K. Jimenez Camacho Inhibition of Src, SIRT1 or HDAC6 Reduces Transendothelial Migration of Acute Lymphoblastic Leukemia B cells 2452
9:15 AM - 9:30 AM A. Almazyad Semaphorin 3F: A Novel Biologic Treatment for Oral Squamous Cell Carcinoma 2668
9:30 AM - 9:45 AM T. Bui Neutrophils Deregulate Tumoral DNA Damage Response and Contribute to Non-Homologous End-Joining (NHEJ)-dependent Survival of Colorectal Cancer 4179
9:45 AM - 10:00 AM A. Fishbein Chemoprevention of Aflatoxin B1-Induced Cytokine Storm and Tumor Dormancy Escape via Dual COX-2/sEH Inhibition 5922
10:00 AM - 10:15 AM S. Verheul Stimulation of Resolution of Inflammation via Pro-Resolving Lipid Mediators Prevents Ethanol-Induced Tumor Growth 5923
10:15 AM - 10:30 AM K. Wadosky Ezh2 loss is a haploinsufficient mediator of cell lineage in prostate cancer and has divergent effect on androgen receptor expression 5981
8:30 AM - 11:30 AM

Symposium: The Gut Microbiota and Disease - Session I
SDCC, Room 2

Chairs: Xiao-Ming Yin, MD, PhD • Indiana University School of Medicine
Co-Chairs: Wenke Feng, PhD • University of Louisville
Maria Pilar Alcaide, PhD • Tufts University School of Medicine
José Otero, MD, PhD • The Ohio State University

Session Description:  Humans carry a vast number of bacteria and other microbiota species from birth, and you may be more bacteria than you are you. An increasing importance of microbiota in human health and diseases has been recognized. Whatever your research subjects are, chances are that they may be influenced by the microbiota. This symposium will discuss the impact of gut microbiota on diseases ranging from neurodegeneration to diabetes, from the liver to the heart, and from the immune cells to the bone. See speakers and presentation titles

8:30 AM - 10:30 AM

Minisymposium: Pathobiology of Cardiovascular Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
8:30 AM - 8:45 AM M. Shoykhet Differential regulation of cardiomyocyte cohesion by signaling pathways involve ERK1/2 or Plakoglobin 694
8:45 AM - 9:00 AM S. Rajalingam Deletion of the Microtubule-associated protein tau (Mapt-/-) results in diastolic heart failure and altered skeletal muscle function in vivo 2885
9:00 AM - 9:15 AM J. Powers Cardiac-specific Deletion of Filamin C Decouples Myocyte Contractility and Calcium Handling in Adult Mice 4277
9:15 AM - 9:30 AM F. Carrillo-Salinas Gut Dysbiosis Induced by Cardiac Pressure Overload Promotes T Cell Activation and Adverse Cardiac Remodeling Through Alterations in the Aryl Hydrocarbon Receptor Expression 4396
9:30 AM - 9:45 AM R. Mitra High Fat Diet versus Disturbed Blood Flow Conditions: Implications for Endothelial Glycocalyx Integrity and Pre-Atherosclerotic Inflammation 5944
9:45 AM - 10:00 AM M. Kowara The influence of high fat, high cholesterol diet on expression of myocardial remodelling biomarkers in the mouse model of atherosclerosis ApoE-/- 6157
10:00 AM - 10:15 AM M. Alsahly Relative Profibrotic Gene Expression in Cardiac Fibroblasts from Low Aerobic Capacity “Disease Prone” Rats Following Ischemic Reperfusion 7377
10:15 AM - 10:30 AM E. Kwan Investigating the effects of Progressive Right Ventricular Remodeling on Systolic and Diastolic RV Function in a Longitudinal Animal Model Study of Pulmonary Arterial Hypertension 7388
11:00 AM - 1:00 PM

ASIP Highlights Session: I Am An ASIP Member and This Is My Science
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Marina Ballroom, Salon G

Chair: Edward A. Medina, MD, PhD • University of Texas Health Science Center
Co-Chair: Titus A. Reaves, PhD • Medical University of South Carolina
Nakisha Rutledge, BSc • Northwestern University

Session Description:  As a Society, we cannot escape the identity crisis we have confronted in the past - what is pathology and how do pathologists fit into the basic framework of biomedical science? This is an ongoing challenge that requires our members to educate others regarding the nature of the discipline of experimental pathology and how our research describes and investigates the pathology, pathogenesis, and pathophysiology of specific diseases at the molecular, cellular, organ, and organismal level. Overcoming this identity crisis requires effort on the part of each ASIP member and our success will be evident as we continue to attract bright and enthusiastic young investigators into the diverse field of experimental pathobiology.

The American Society for Investigative Pathology presents I Am An ASIP Member and This Is My Science a dynamic and inspiring session featuring ASIP Scientists on the Cutting Edge of Discovery briefly, present their research, accomplishments, career journeys, and service to ASIP. This session highlights the diversity among our membership, and provides trainees, young scientists, pathologists, and the members of the larger scientific community the opportunity to become inspired by Trailblazers in the field of investigative pathology. See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: Disease Modeling with iPSC: From Cells to Organoids
SDCC, Room 3

Chair: Philip M. Iannaccone, MD, PhD • Northwestern University Medical School
Co-Chairs: Satdarshan Paul Singh Monga, MD • University of Pittsburgh School of Medicine
Ivana Delalle, PhD, MD • Boston University School of Medicine

Session Description:  The availability of human iPSC from various disease states presents an unprecedented opportunity to examine pathology and physiology in an intact tissue context. The decades since the early descriptions of stem cell derived “embryoid bodies”, the first example of “organoids”, have seen major advances in directed differentiation of stem cells and their organization into small structures mimicking normal organs. Organoids can be used to interrogate altered physiology and toxicology or as test beds for therapeutic intervention. Patient derived iPSC have been used to advance our understanding of many aspects of disease states. This session will highlight recent advances in both organoids and the use of directed differentiation of human iPSC in the study of disease. See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: The Gut Microbiota and Disease - Session II
SDCC, Room 2

Chair: Xiao-Ming Yin, MD, PhD • Indiana University School of Medicine
Co-Chairs: Wenke Feng, PhD • University of Louisville
Maria Pilar Alcaide, PhD • Tufts University School of Medicine
José Otero, MD, PhD • The Ohio State University

Session Description:  Humans carry a vast number of bacteria and other microbiota species from birth, and you may be more bacteria than you are you. An increasing importance of microbiota in human health and diseases has been recognized. Whatever your research subjects are, chances are that they may be influenced by the microbiota. This symposium will discuss the impact of gut microbiota on diseases ranging from neurodegeneration to diabetes, from the liver to the heart, and from the immune cells to the bone. See speakers and presentation titles

2:00 PM - 5:00 PM

Minisymposium: Neuropathobiology
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
2:00 PM - 2:15 PM Y. Chang Loss-of-Function Aldolase C Hypermethylation Cause Serotonin Production in Glioblastoma 332
2:15 PM - 2:30 PM V. Khammad Machine learning applications in R for the differentiation of primary CNS tumors 1778
2:30 PM - 2:45 PM K. Belsare Interaction of sTREM2 with Amyloid Beta: Implication on the Protective Role of sTREM2 in Alzheimer’s Disease 1844
2:45 PM - 3:00 PM C. Chu Chemical Inhibition of PTEN-Induced Kinase 1 (PINK1) Degradation Confers Neuroprotection in Culture Models of Parkinson’s Disease 1984
3:00 PM - 3:15 PM A. Mondal Essential role of NFATC4-S-palmitoylation to promote IP3R1-expression required for lysosomal Ca++ homeostasis dysregulated in INCL mice 2484
3:15 PM - 3:30 PM V. Kulchitsky Antitumor Effects of Mesenchymal Stem Cells 2700
3:30 PM - 3:45 PM E. Saito Metabolic RNA-seq profiles from sporadic Alzheimer’s disease patients: Analysis of glycolytic and ketolytic pathways 3717
3:45 PM - 4:00 PM W. Chen Magnetic and Ultrasonic Guidance of Iron–Platinum Nanoparticles Encapsulated in Multifunctional Lipid Bubbles for Conquering the Blood-Brain Barrier with Improved Theranostics 3808
4:00 PM - 4:15 PM K. Oberman Mixed Effects Of Active Immunization Against Aß In An Alzheimer Mouse Model 5087
4:15 PM - 4:30 PM E. Bearer Brain connectivity and activity during Alzheimer's disease progression in a mouse model by manganese--enhanced MRI in living brain correlated with post-mortem histopathology 6114
4:30 PM - 4:45 PM V. Suryadevara A First Report of altered bone microarchitecture in a commonly used mouse model of Alzheimer Disease (5XFAD Tg+) 6700
4:45 PM -5:00 PM J. Callender Manipulating PrP Glycan Structure to Understand Toxic Signaling Pathways Driving Prion-Induced Neurodegeneration 8717
5:00 PM - 7:00 PM

Women in Pathology Social
SDCC, Room 4

Leader: Linda McManus, PhD • University of Texas Health San Antonio
Co-Leaders: Maria Pilar Alcaide, PhD • Tufts University School of Medicine
Nakisha Rutledge, BSc • Northwestern University

Social Description:  Women in Pathology is a new community within the membership of the American Society for Investigative Pathology (ASIP) that is focused on issues that face women in science, and is committed to recognizing women’s scientific achievements and fostering their career development and advancement in pathobiology research. Women in Pathology will address challenges for women in science at every stage of career and life – as trainees, as active biomedical researchers, during transitions into career breaks required for family life, during transitions back into professional life as a mother, and as advanced investigators. Women in Pathology will provide innovative opportunities for engagement by women in science to participate in productive networking, development of meaningful professional partnerships, and mentoring.

6:00 PM - 7:00 PM

EB-Wide Tang Prize Award Lecture
Tyrosine Phosphorylation - From Discovery to Drug Development and Beyond

Tony Hunter, PhD • Salk Institute for Biological Studies

7:00 PM - 8:30 PM

EB-Wide Welcome Reception
SDCC, Sails Pavilion

7:00 PM - 9:00 PM

The AJP Editorial Board Dinner
(By Invitation Only)

Reception Description: Join your fellow attendees at the conference-wide reception to meet, greet, and mingle. Appreciate the power and energy of the EB Meeting as all career levels come together for fun, socialization, and networking.

 

Sunday, April 5, 2020

 

7:00 AM - 8:00 AM

ASIP Committee for Career Development and Diversity (CCDD) and Education Committee Meeting
SD Marriott Marquis & Marina • Del Mar Meeting Room

8:00 AM - 9:00 AM

Histochemical Society Leadership Meeting
SDCC, Room 5B

8:00 AM - 10:30 AM

Blood Vessel Club™ Gut Microbiota in Vascular Disease
Sponsored by the ASIP Inflammation/Immunopathology Scientific Interest Group and the Vascular and Mucosal Pathobiology Scientific Interest Group
SDCC, Room 3

Chair: Jonathon W. Homeister, MD, PhD • University of North Carolina at Chapel Hill
Co-Chair: Denuja Karunakaran, PhD • The University of Queensland

Session Description:  This symposium explores the newest discoveries into the role the gut microbiome has in the pathobiology of vascular diseases. Presentations by national and international experts in the field will focus on the mechanisms by which the gut microbiome can modulate both atherosclerotic vascular disease and hypertensive vascular disease. See speakers and presentation titles

10:00 AM - 10:30 AM

Young Scientist Leadership Award Lecture
[Presented in conjunction with the Blood Vessel Club™  Gut Microbiota in Vascular Disease Session]

  • Chair Introduction
  • RIP Kinases in Cardiometabolic Diseases
    Denuja Karunakaran, PhD • The University of Queensland, Brisbane, Australia
8:00 AM - 10:00 AM

Breast Cancer Workshop - Tumor Microenvironment in Breast Cancer Progression
Sponsored by the ASIP Breast Cancer Scientific Interest Group
SDCC, Room 2

Chair: Bethany Hannafon, BS, PhD • University of Oklahoma Health Sciences Center
Co-Chair: Piyali Dasgupta, PhD • Marshall University

Session Description:  This session will examine the role of the tumor microenvironment in primary breast cancer development to metastatic dissemination and therapeutic resistance. Attendees will hear from leaders in the breast cancer field about tumor-host crosstalk mediated by extracellular vesicles, the role of the immune microenvironment in cancer progression, tumor cell dormancy and its role in therapeutic resistance, and the role of the lymph node tumor microenvironment in the progression of lymph node breast cancer metastases. See speakers and presentation titles

10:00 AM - 10:30 AM

Outstanding Investigator Award Lecture
[Presented in conjunction with the Breast Cancer Workshop]

SDCC, Room 2

  • Introduction
  • Understanding Breast Cancer: My Journey as a Physician-Scientist
    Celina Kleer, MD • University of Michigan
8:00 AM - 10:00 AM

Society of Toxicologic Pathology (STP) Symposium: Animal models in Basic Research and Preclinical Science: The Critical Role of the Toxicologic Pathologist
Sponsored by the ASIP Environmental and Toxicologic Pathology Scientific Interest Group
SDCC, Room 5A

Chair: Mark Hoenerhoff, DVM, PhD • University of Michigan
Co-Chair: Jack Harkema, PhD, DVM • Michigan State University

Session Description:  Veterinary toxicologic pathologists play an integral role in biomedical and basic sciences, through translation of preclinical in vivo data for the study of human disease, development of new technologies and medical interventions, and drug development. Toxicologic pathologists also play a role in determination of chemical/drug adversity in animals and humans, and help predict relevance to humans taking into account mechanisms and margin of safety.

Working with researchers, clinicians, and toxicologists, toxicologic pathologists can help facilitate a better understanding of disease processes through interpretation of animal models, drug development, and improve translatability of preclinical data in the “bench to bedside” approach to patient care. Through expanding interdisciplinary collaborations with the human medical field and other disciplines, toxicologic pathologists are central to the “One Health” concept at the intersection of all aspects of health care for humans, animals, and environmental health. This session will showcase the role veterinary toxicologic pathologists play in basic research, investigative pathology, drug development, and imaging modalities to strengthen translatability of animal data to the clinic in collaboration with other scientists. This session will also highlight how toxicologic pathologists can inform on the validity, use, relevance, and power of animal models to study human disease. See speakers and presentation titles

8:30 AM - 11:30 AM

Symposium: The Great Debate - Fibrosis Across Organs: Triggers, Pathways, and Cellular Plasticity
Co-Sponsored by the American Society for Matrix Biology (ASMB)
SDCC, Room 4

Chair: Titus A. Reaves, PhD • Medical University of South Carolina
Co-Chair: Tirthadipa Pradhan-Sundd, PhD • University of Pittsburgh

Session Description:  Fibrosing diseases are a broad spectrum of entities from organ-specific involvement to multi-system diseases with high morbidity and mortality and significantly unmet clinical needs. Progress in elucidating the pathogenesis of the fibroproliferative components across various diseases, including the critical roles of key cell types and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis, has highlighted many new areas of therapeutic investigation and are currently underway. This session is designed to bring together translational biomedical researchers from a wide range of disciplines to discuss complex pathophysiologic mechanisms that underlie fibrosing diseases. You won’t want to miss the hot topic debate on Power Cell – Fibroblast or Macrophage that will follow the session talks. See speakers and presentation titles

9:00 AM - 4:00 PM

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

  • Cancer I
  • Inflammation and Disease
  • Liver Pathobiology I
  • Mucosal/Epithelial Pathobiology
  • Neuropathology
  • Stroke
  • The Science of Diabetes
11:00 AM - 1:00 PM

Planning for Success: Navigating Your First Faculty Position
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Carlsbad Cardiff

Chair: Christi Kolarcik, PhD • University of Pittsburgh
Co-Chair: Traci Parry, PhD • University of North Carolina at Greensboro

Session Description:  Feeling overwhelmed as you wrangle your first faculty position? Come hear from our experienced faculty as they impart valuable advice and tactics on successfully planning, transitioning into, adapting, (and surviving!) your first years as a faculty member. See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: Fixing Fatty Liver
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group
SDCC, Room 2

Chair: Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh School of Medicine

Session Description:  In this session, we will approach the problem of non-alcoholic fatty liver disease (NAFLD) through improved understanding of the cellular and molecular mechanisms involved in disease progression. Recent advances in gut-liver axis, microbiome, and inflammation in the pathogenesis of NAFLD will be also discussed. Finally, we will explore novel signaling pathways that can be targeted for treatment of NAFLD. See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: Novel Regulators and Functions of Epithelial Junctions
SDCC, Room 4

Chair: Sean Colgan, PhD • University of Michigan
Co-Chair: William Muller, MD, PhD • Northwestern University

Session Description:  Epithelial junctions are key regulators of tissue integrity and homeostasis, and their compromise contributes to the pathogenesis of inflammatory and immune disorders. This symposium will highlight recent developments in this exciting area of research and will touch upon developmental and disease pathways. The talks will cover the role of intercellular junction proteins in a range of tissues, including simple and complex epithelia. See speakers and presentation titles

2:00 PM - 5:00 PM

Pathobiology Course for Research Scientists: Resolution of Inflammation
Sponsored by the ASIP Education Committee
SDCC, Room 5A

Chair: Dipak Panigrahy, MD • Beth Israel Deaconess Medical Center/Harvard Medical School
Co-Chair: Alexander Sougiannis, BS, MA • University of South Carolina School of Medicine

Session Description:  Unresolved inflammation is a major mechanism of pathogenesis in many human diseases. A paradigm shift is emerging in our understanding of the pathogenesis of inflammation which results not only from persistent activation of inflammatory signals, but also from the active loss of pro-resolution mechanisms. Differentiating between the suppression and resolution of inflammation driven by pro-resolution mediators is critical for the treatment of various inflammatory diseases. See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: Coagulation and Fibrinolytic Factors and Innate Immunity
SDCC, Room 3

Chair: Wendy Mars, PhD • University of Pittsburgh Medical School
Co-Chair: Steven Gonias, MD, PhD • University of California, San Diego

Session Description:  Proteins involved in both the coagulation and fibrinolysis pathways do much more than their well-described historical roles affecting the formation and dissolution of clots. This session will highlight data from leaders in the field who are studying the function of hemostasis factors in innate immunity. See speakers and presentation titles

5:00 PM - 6:00 PM

Rous-Whipple Award Lecture
SDCC, Room 2

  • Introduction
  • Exploring Precision Oncology: From Gene Fusions to Genomic Instability
    Arul Chinnaiyan, MD, PhD • University of Michigan
6:00 PM - 8:00 PM

Scientific Interest Groups (SIG) Interactive Poster Discussions, Networking Sessions, Award Presentations and Reception
Room TBD

Interactive Discussions of Invited Posters Presenters which Represent the SIGs of the ASIP

7:00 PM - 8:00 PM

Club Hepatomania™ - Meet the Liver Experts
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group

SDCC, Ballroom BC

7:00 PM - 9:00 PM

Histochemical Society Business Meeting, Awards Presentations, and Reception
Horton Grand Hotel Atrium

 

Monday, April 6, 2020

 

7:00 AM - 8:00 AM

ASIP Town Hall Meeting and Breakfast
SDCC, Room 5A

Chair: Dani S. Zander, MD • University of Cincinnati Medical Center
Co-Chair: William B. Coleman, PhD • American Society for Investigative Pathology

Session Description:  Are you a new member of the ASIP and want to become more involved? Are you interested in working with the ASIP leadership and committees? Join us for breakfast and open conversation in a casual enviorment where we network together with the common goal of building a stronger ASIP.

8:30 AM - 10:30 AM

Minisymposium: Pathobiology of Lung Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
8:30 AM - 8:45 AM R. Nho E-Cigar Vapor Alters Lung Fibroblast Viability via Alpha 7 Nicotine Acetylcholine Receptor 2627
8:45 AM - 9:00 AM M. Chan Upconversion Nanoparticles Induce Lung Inflammatory, Immunologic and Pulmonary Injury in Vivo 3801
9:00 AM - 9:15 AM K. Hirschi-Budge Acute eCig Vapor or SHS Exposure Induces Inflammatory Signaling in the Adult Murine Lung 4232
9:15 AM - 9:30 AM K. Hendee Mechanosensitive Mechanism of Lung Regeneration through Endothelial YAP1 4234
9:30 AM - 9:45 AM E. Bontekoe Upregulation of Inflammatory Biomarkers in Pulmonary Embolism as Studied by a Biochip- Array Profiling Approach 4578
9:45 AM - 10:00 AM J. Dye Differential Lung Responses to Early Life Ozone Exposure in Male and Female Rat Offspring 6436
10:00 AM - 10:15 AM J. Goral Characterization of Fibrotic Changes in the Lungs of Mice Following Oral Administration of 4NQO 6715
10:15 AM - 10:30 AM M. Sunday Hyperoxic Lung Injury in Newborn Mice is Abrogated by Neutralizing mAb 2A11 to Gastrin-Releasing Peptide (GRP) 6814
8:30 AM - 11:30 AM

Symposium: Emerging Technologies From the Bench Disrupting Diagnosis and Care Near the Bedside
SDCC, Room 2

Chair: Nathan Montgomery, MD, PhD • University of North Carolina, Chapel Hill
Co-Chair: Gregory Tsongalis, PhD • Dartmouth-Hitchcock Health System

Session Description:  This session will explore emerging genomic and molecular diagnostic tools that are being rapidly adopted in patient care, in the process transforming and disrupting the standard approach to clinical challenges as diverse as newborn diagnostics, microbiology, and oncology. See speakers and presentation titles

8:30 AM - 11:30 AM

Symposium: Mechanisms of Hepatic Turmorigenesis
Sponsored by the ASIP Liver Pathobiology Scientific Interest Group
SDCC, Room 3

Chair: Satdarshan Paul Singh Monga, MD • University of Pittsburgh School of Medicine
Co-Chair: Heather Francis, PhD, FAASLD • Indiana University

See speakers and presentation titles

8:30 AM - 11:30 AM

VAMP Symposium: Immune Regulation of Barrier Forming Cells
Sponsored by the ASIP Vascular and Mucosal Pathobiology Scientific Interest Group
SDCC, Room 4

Chair: Jennifer Brazil, PhD • University of Michigan
Co-Chair: Francis W. Luscinskas, PhD • Brigham & Women's Hospital

See speakers and presentation titles

9:00 AM - 4:00 PM

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

  • Cancer II
  • Cell Death, Injury, and Repair
  • Environmental and Toxicological Pathology
  • Infectious Disease I
  • Liver Pathobiology II
  • Lung Pathobiology
  • Vascular Biology
10:00 AM - 10:45 AM

Cotran Early Career Investigator Award Lecture
SDCC, Room 5A

  • Introduction
  • Studying Oxygen Sensing Pathway in Cancers
    Qing Zhang, PhD • UT Southwestern Medical Center
11:00 AM - 1:00 PM

Workshop: Career Speed-Networking Luncheon: Conversations with Experts
Sponsored by the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • San Diego Ballroom, Salon A

Chair: Verónica Contreras-Shannon, PhD • St. Mary's University
Co-Chair: Morgan Preziosi, BS, BA • University of Pennsylvania Perelman School of Medicine

Session Description:  From Academia to Patent Law, at this speed-networking lunch event, you'll have the chance to discuss diverse career opportunities, what skills you need to be successful in these careers, how to get your foot in the door, and so much more! See speakers and presentation titles

12:00 PM - 2:00 PM

HCS, ASIP, AAA Symposium: Geographic Information System (GIS) for Tissues and Tumors: Mapping Quantitative Data into an Anatomical Context
SDCC, Room 6E

See speakers and presentation titles

1:00 PM - 1:30 PM

Young Scientist Leadership Award Lecture
SDCC, Room 4

  • Chair Introduction
  • Exercise Oncology: Harnessing the Therapeutic Benefits of Exercise
    Traci L. Parry, PhD • University of North Carolina at Greensboro
2:00 PM - 3:00 PM

The Journal of Histochemistry & Cytochemistry Lecture
SDCC, Room 6E

Chair: Stephen Hewitt, MD, PhD • Editor, Journal of Histochemistry and Cytochemistry • National Cancer Institute/National Institutes of Health

Session Description:

  • Gender Diversity in Innovation Toolkit Created by IPO
    Mercedes K. Meyer, PhD, JD • Drinker Biddle and Reath, LLP
2:00 PM - 5:00 PM

Presidential Symposium: Advances in Regenerative Medicine
SDCC, Room 2

Chair: Carol Farver, MD • Cleveland Clinic
Co-Chair: James Stone, MD, PhD • Massachusetts General Hospital

See speakers and presentation titles

2:00 PM - 5:00 PM

Symposium: Deep Learning and Artificial Intelligence in Pathology
SDCC, Room 3

Chair: Stanley Cohen, MD • Rutgers-New Jersey Medical School
Co-Chair: John Tomaszewski, MD • University at Buffalo School of Medicine

See speakers and presentation titles

2:00 PM - 5:00 PM

Minisymposium: Pathobiology of Cancer II
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
2:00 PM - 2:15 PM J. Starrett Drug Sensitivity and Allele-specificity of First-line Osimertinib Resistance EGFR Mutations 612
2:15 PM - 2:30 PM P. Mendonca The role of NF&[kappa]B in pentagalloyl glucose inhibition of TNF-&[alpha]-induced CXCL1 expression and induction of apoptosis-related genes in racially different triple negative breast cancer cells 1962
2:30 PM - 2:45 PM J. Hong TMEM49 induced ovarian cancer via apoptosis pathway 2074
2:45 PM - 3:00 PM V. Hira Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies 2101
3:00 PM - 3:15 PM R. Castellanos Martinez The Role of the Actin-Binding Protein Cortactin in the Activation of T Cells: Implications for T-Cell Acute Lymphoblastic Leukemia 2268
3:15 PM - 3:30 PM J. Okada High expression of Nucleobindin-2 is associated with poor prognosis in gastric cancer 2410
3:30 PM - 3:45 PM L. Li Novel Tumor Suppressor PMM1 Suppresses Oral Cancer Growth through Activation Unfolding Protein Response Activator EGR1 3127
3:45 PM - 4:00 PM S. Huang Over-expression of BICD1 gene as a marker for clinically predicting Temozolomide resistance in Glioblastomas 4991
4:00 PM - 4:15 PM C. Fang High Expression of F11R/JAM-A is Predominant in Triple-negative Breast Cancer Subtype and Correlates with Poor Prognosis in Breast Cancer Patients 5014
4:15 PM - 4:30 PM Y.Wu Meta-Analysis Reveals Gut Microbial Signatures in Colorectal Adenoma and A Link with Secondary Bile Acid Conversion 5174
4:30 PM - 4:45 PM S. Eliason Inhibition of colorectal tumor formation using a new miR-210 therapeutic inhibitor that targets the Lnc RNA Xist and Nme1 5559
4:45 PM - 5:00 PM V. Hallisey Pro-Resolving Lipid Mediators and Anti-Angiogenic Therapy Exhibit Synergistic Anti-Tumor Activity via Resolvin Receptor Activation 5830
5:15 PM - 7:30 PM

ASIP Business Meeting, Awards Presentations, and Reception
SDCC, Room 2

8:00 PM - 11:00 PM

ASIP President’s Reception
Room TBD (By Invitation Only)

 

Tuesday, April 7, 2020

 

7:00 AM - 8:00 AM

ASIP Program Committee Meeting
San Diego Marriott Marquis & Marina • Del Mar Meeting Room

8:00 AM - 10:00 AM

XXth Annual Workshop in Graduate Education in Pathology
Sponsored by the ASIP Education Committee
San Diego Marriott Marquis & Marina • Marina Ballroom, Salon D

Chair: Titus A. Reaves, PhD • Medical University of South
Co-Chair: José Otero, MD, PhD • The Ohio State University

See speakers and presentation titles

8:30 AM - 10:30 AM

Minisymposium: Epithelial and Mucosal Pathobiology I
SDCC, Room 14B

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
8:30 AM - 8:45 AM A. Siddiq Giardia extracellular vesicles disrupt intestinal epithelial junctions and inhibit the growth of commensal bacteria while increasing their swimming motility 515
8:45 AM - 9:00 AM K. Crakes PPAR&[alpha]-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection 2382
9:00 AM - 9:15 AM A. Sigmund Dsg2 Upregulation as a Rescue Mechanism in Pemphigus 2757
9:15 AM - 9:30 AM T. Schmitt Ca2+ signalling is important for loss of keratinocyte adhesion in pemphigus vulgaris 2870
9:30 AM - 9:45 AM M. Kelm Targeting Epithelial Expressed Sialylated Lewis glycans improves colonic mucosal wound healing and protects against colitis 4718
9:45 AM - 10:00 AM R. Wang Dynamic regulation of actin-binding protein synaptopodin by butyrate promotes intestinal epithelial barrier function 4761
10:00 AM - 10:15 AM Y. Ghoreishi ADAM10 and Src-signalling contribute to the inflammation-induced formation of VE-cadherin fragments in endothelial cells 5100
10:15 AM - 10:30 AM M. Quiros Resolvin E1 is a pro-repair mediator that promotes intestinal epithelial wound healing 6041
8:30 AM - 10:30 AM

Liver Pathobiology I
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
8:30 AM - 8:45 AM V. Meadows Mast Cell Signaling Regulates Biliary Farnesoid X Receptor and Apical Sodium Bile Acid Transporter Expression During Cholestatic Liver Injury 2044
8:45 AM - 9:00 AM E. Delgado Diploid Hepatocytes Resist Acetaminophen Induced Acute Liver Injury and Drive Compensatory Liver Regeneration 4188
9:00 AM - 9:15 AM M. McMillin Inhibition of thrombospondin-1 reduces transforming growth factor beta 1 signaling, hepatic fibrosis and neurological deficits during cholestasis in rats 5155
9:15 AM - 9:30 AM J. Tao Concomitant NFE2L2 and CTNNB1 mutations in a subset of HCC patients: Synergy between Nrf2 and Wnt pathway in hepatocarcinogenesis 5247
9:30 AM - 9:45 AM B. Bhushan Hepatic deletion of MET aggravates acetaminophen hepatotoxicity and impairs liver regeneration in mice 5879
9:45 AM - 10:00 AM A. O'Brien FGF1 receptor antagonist decreases biliary proliferation, fibrosis, and senescence in a mouse model of chronic cholestasis 6501
10:00 AM - 10:15 AM T. Pradhan-Sundd Hepatocyte specific ablation of &[beta] and &[gamma]-catenin leads to altered hepatocyte polarity and EMT induction 7151
10:15 AM - 10:30 AM A. Mondal Butyrate Priming Improves Gut Health by Modulating Host Protease Activity in Murine Non-Alcoholic Fatty Liver Disease 7464
8:30 AM - 11:30 AM

Symposium: Precision Oncology: The Promise for Translating Personal Genomics into Clinical Action
SDCC, Room 4

Chair: Kevin Gardner, MD, PhD • Columbia University Medical Center
Co-Chair: Elizabeth Whitley, DVM, PhD • MD Anderson Cancer Center

See speakers and presentation titles

8:30 AM - 11:30 AM

Symposium: Drinking from the Firehose: Progress in the Practical Uses of Big Data
SDCC, Room 2

Chairs: Dan Milner, Jr., MD, MSc, FASCP • American Society for Clinical Pathology
Co-Chair: Kevin Gardner, MD, PhD • Columbia University Medical Center

See speakers and presentation titles

8:30 AM - 10:30 AM

ACVP-ASIP Symposium: Hemostasis and Thrombosis
Sponsored by the ASIP Veterinary and Comparative Pathology Scientific Interest Group and the American College of Veterinary Pathologists (ACVP)
SDCC, Room 3

Chair: Nora L. Springer, DVM, DACVP • Kansas State University College
Co-Chair: Katherine N. Gibson-Corley, DVM, PhD, DACVP • University of Iowa

Session Description:  Veterinary scientists discuss cutting edge research in canine hemostasis and thrombosis and correlate to the equivalent human disease. See speakers and presentation titles

9:30 AM - 2:30 PM

ASIP Scientific Sleuthing of Human Disease for Undergraduate Students and High School Teachers and Students
Sponsored by the ASIP Education Committee
SD Marriott Marquis & Marina • Marina Ballroom, Salon G

Chair: Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh School of Medicine
Co-Chair: Martha B. Furie, PhD • Stony Brook University

See speakers and presentation titles

9:00 AM - 4:00 PM

Poster Viewing - Pathology, Pathogenesis, and Pathobiology
SDCC, Exhibit Halls A-D

Topics: 

  • Bioinformatics and Pathology Education
  • Cardiac Pathobiology
  • Endocrine Pathology
  • Gene Expression
  • Hemostasis and Thrombosis
  • Infectious Disease II
  • Metabolic Disorders
  • Microscopy and Imaging
  • Renal Pathology
  • Veterinary Pathology
11:45 AM - 1:45 PM

Lunch and Learn: The ABC of the IDP, A Mentoring Workshop
Sponsored by the ASIP Education Committee and the ASIP Committee for Career Development and Diversity
San Diego Marriott Marquis & Marina • Marriiott Grand Ballroom 1-2

Chair: Roberto Ivan Mota Alvidrez, MD, MS • University of North Carolina at Chapel Hill
Co-Chair: Christi Kolarcik, PhD • University of Pittsburgh

See speakers and presentation titles

2:00 PM - 5:00 PM

SCVP-ASIP Joint Symposium: Clonal Hematopoiesis: Impact on Inflammation and Cardiovascular Disease - Cardiac Pathology
Sponsored by the ASIP Inflammation/Immunopathology Scientific Interest Group and the Society for Cardiovascular Pathology (SCVP)
SDCC, Room 2

Chair: James Stone, MD, PhD • Massachusetts General Hospital

See speakers and presentation titles

2:00 PM - 5:00 PM

SIPMeT Symposium: Epigenetic Regulation and Cancer
Sponsored by ASIP and the Società Italiana di Patologia e Medicina Traslazionale/Italian Society of Pathology and Translational Medicine (SIPMeT)
Co-Sponsored by the ASIP Gene Regulation Scientific Interest Group

SDCC, Room 3

Chair: Massimiliano Corsi Romanelli, PhD, MD • University of Milan, Milan Italy
Co-Chair: Fancesco Curcio, MD • University of Udine, Udine, Italy

See speakers and presentation titles

2:00 PM - 5:00 PM

Minisymposium: Liver Pathobiology II
SDCC, Room 4

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
2:00 PM - 2:15 PM K. Kosar Determining the effects of Wnt signaling in the alleviation of cholestasis via the promotion of hepatocyte transdifferentiation 1842
2:15 PM - 2:30 PM S. Kumar Deficiency of Augmenter of Liver Regeneration is Critical Predisposing Factor for Nonalcoholic Steatohepatitis and Fibrosis 2347
2:30 PM - 2:45 PM L. Kennedy Mast Cell (MC) Activation and Histamine (HA) Signaling Promotes Atypical Ductular Reaction, Biliary Senescence and Liver Fibrosis During Advanced Stage Primary Biliary Cholangitis (PBC) 2713
2:45 PM - 3:00 PM A. Sharma Hepatic stellate cells are critically involved in modulation of inflammatory microenvironment during acute liver injury 2886
3:00 PM - 3:15 PM W. Ma The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway 2931
3:15 PM - 3:30 PM E. Delgado Deletion and Overexpression of the Scaffolding Protein IQGAP1 Promotes Hepatocellular Carcinoma 2971
3:30 PM - 3:45 PM C. Walesky Functional Compensation Precedes Recovery of Tissue Mass Following Acute Liver Injury 3650
3:45 PM - 4:00 PM X. Chao Trehalose Does Not Improve Alcohol-Impaired TFEB and Liver Injury in Mice 3758
4:00 PM - 4:15 PM L. Molina Novel Model of Bile Duct Paucity Demonstrates the Critical Role of Yap1 in Biliary Morphogenesis in Development and Regeneration 4668
4:15 PM - 4:30 PM S. Ko Simultaneous Yap and Sox9 repression eliminates Notch-dependent hepatocyte-driven cholangiocarcinogenesis 4899
4:30 PM - 4:45 PM K. Koral Lymphocyte Specific Protein-1 suppresses TCPOBOP induced hepatocellular proliferation 5213
4:45 PM - 5:00 PM M. Preziosi LXR Agonism Potentiates Sorafenib Activity in HCC By Inducing Metabolic Stress 6520
2:00 PM - 5:00 PM

Minisymposium: Pathobiology of Infectious Disease
SDCC, Room 5A

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
2:00 PM - 2:15 PM H. Gorman Role of MUC2 Mucin Associated FCGBP in Innate Host Defense Against Entamoeba Histolytica 15
2:15 PM - 2:30 PM G. Golden Sulfation of endothelial heparan sulfate mediates Staphylococcus aureus induced hepatotoxicity 681
2:30 PM - 2:45 PM N. Lartey The Role of the Actin-Binding Protein Cortactin in the Onset and Development of Sepsis 2035
2:45 PM - 3:00 PM E. Fekete Alterations to Mucus Production and Secretion during Giardia Infection Involve Giardia Protease Activity and PAR2 Activation 2365
3:00 PM - 3:15 PM P. Bernard Polymorphisms in RocA contribute to the molecular pathogenesis of serotype M28 group A streptococcus 3097
3:15 PM - 3:30 PM A. Awan Characterization of Viraemic Cells in a Murine Model of EHV-1 Infection 3232
3:30 PM - 3:45 PM P. Hanson Induction of Nrg1 and ErbB4 Is Specific to Virus Induced Injury of the Myocardium and May be Detected during Pathogenesis of Viral Myocarditis as Blood-Based Biomarkers for Diagnosis 4191
3:45 PM - 4:00 PM D. Josh Altered Coagulation Parameters and D-Dimer Measurements in Sepsis are useful in Scoring the Risk Stratification 4208
4:00 PM - 4:15 PM M. Engevik Characterizing mucus-based biofilms in human Clostridium difficile infection 4534
4:15 PM - 4:30 PM J. Mungin Human Vaginal Epithelial Cells are Susceptible to the Zika Virus: Implications for Zika Vaginal Transmission 7170
4:30 PM - 4:45 PM C. Morris Heparan Sulfate Modulates Heart Vascular Remodeling Induced by S. Aureus Sepsis 7339
4:45 PM - 5:00 PM T. Allain Western Diet Increases the Severity of Giardia Infection in Association with Gut Microbiota Dysbiosis 7347
2:00 PM - 5:00 PM

Minisymposium: Epithelial and Mucosal Pathobiology II
SDCC, Room 14BA

Abstract-Driven Short Talks (15-minutes each)

Presentation Time Presenting Author Abstract Title Abstract No.
2:00 PM - 2:15 PM S. Rahaman Role of TRPV4 mechanosensing in foreign body response and giant cell formation 1995
2:15 PM - 2:30 PM S. Cheng FUT2 deficiency may influence the pathogenesis of inflammatory bowel diseases through gut microbiome 2866
2:30 PM - 2:45 PM S. Cheng NMI and IFP35 are key DAMP molecules in inflammatory bowel diseases 3147
2:45 PM - 3:00 PM I. Cartwright Insights into the mechanisms of inflammatory acidification within the mucosa 3559
3:00 PM - 3:15 PM C. Austin A Randomized, Placebo-Controlled Trial Evaluating Effects of Lebrikizumab on Airway Eosinophilic Inflammation and Remodeling in Uncontrolled Asthma (CLAVIER) 3747
3:15 PM - 3:30 PM T. Mammoto Obesity in Vascular and Alveolar Morphogenesis after Pneumonectomy 4154
3:30 PM - 3:45 PM Y. Guo The Roles of Inducible Nitric Oxide Synthase in Mediating the Effects of Embryotoxic Cytokines on Mouse Embryonic Cells 4158
3:45 PM - 4:00 PM J. Brazi Regulation of Neutrophil Function by Selective Targeting of Glycan Epitopes Expressed on the Integrin CD11b/CD18 4566
4:00 PM - 4:15 PM D. Sullivan Calcium Signaling Regulates Leukocyte Transendothelial Migration through the Action of Endothelial Cell IQGAP1, Calmodulin, and CaMKII&[delta] 5149
4:15 PM - 4:30 PM J. Lanis Contributions of Creatine Kinase to Mucosal Immune Responses in Colitis 5630
4:30 PM - 4:45 PM N. Rutledge CD99L2 is a Major Regulator of Transendothelial Migration 5691
4:45 PM - 5:00 PM V. Tanwar Palmitic acid induced lncRNA PARAIL regulates inflammation in human monocytes and macrophages 6582